Future studies are needed to focus on the at-risk population for the etiology investigation of narcolepsy. Diagnostic criteria should be standardized when comparing or pooling the incidence/prevalence to understand the epidemiology of narcolepsy. Incidence/prevalence studies using ICSD and Brighton provided lower estimates than studies using ICD and other criteria. Conclusions: Estimates of incidence/prevalence of narcolepsy could not be pooled reliably with substantial heterogeneity. The incidence was higher for children than adults (OR 1.61, ) and for individuals vaccinated with Pandemrix than those unvaccinated (OR 6.49, ). No significant difference was found in estimates of two rates between ICSD and Brighton. ICD tended to provide higher estimates of incidence/prevalence than Brighton (incidence odds ratio 1.38, prevalence OR 1.50, ). Totally 10 diagnostic criteria were used, including the 1st revised edition of International Classification of Diseases (ICSD-1), ICSD-2, ICSD-3, the 8th revision of International Classification of Diseases (ICD-8), ICD-9, ICD-10, Brighton collaboration case definition (Brighton), Mayo classification, the Ullanlinna Narcolepsy Scale, and clinical symptoms with the multiple sleep latency test. The estimates of incidence and prevalence were wide-ranging with high heterogeneity (incidence I 2 = 99.8% prevalence I 2 = 99.7%), from 0.06 to 6.56 per 100,000 person-years for incidence and from 1.05 to 79.40 per 100,000 population for prevalence, respectively. Results: Thirty-five studies were selected from 2,833 articles. Subgroup analyses and meta-regression were used to assess the impact of diagnostic criteria on incidence/prevalence of narcolepsy after adjusting for age-group, region, study period, vaccination status, index date, and type of narcolepsy. Methods: We searched 5 databases for observational studies on the incidence or prevalence of narcolepsy published before October 14, 2021. We aimed to explore sources of heterogeneity in estimates of incidence and prevalence, with a particular focus on diagnostic criteria. Estimates of incidence and prevalence of narcolepsy vary between studies, while the contribution of changing diagnostic criteria to the variation remains unclear. The diagnostic criteria of narcolepsy evolve from clinical symptoms to molecular biomarkers, along with the understanding of its clinical nature and pathogenesis. Introduction: Narcolepsy is a chronic neurological disorder.

Icd 10 narcolepsy with cataplexy